Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites.
Roche is an equal opportunity employer.
Roche Postdoctoral Fellowship in Chemical-Genetic Screening Of Targeted Protein Degradation (Oncology focus)
As postdoctoral fellow located in Basel, Switzerland, you will be driving a project in the discovery and translational area (DTA) of Oncology at the department of Molecular Targeted Therapy (MTT). The aim of this project is to establish a comprehensive assessment of proteins amenable to Targeted Protein Degradation and identify potential mechanisms of resistance to this novel class of agents. The studies will be focused on Oncology-relevant questions and will require deep integration and collaboration with medicinal chemistry, proteomics and bioinformatics colleagues. Your responsibilities include, but are not limited to:
Plan, perform, and interpret experiments independently to drive the project efficiently
Develop and optimize methods to test degrader molecules in cellular context
Lead through proteomic and mass spectrometry-based methods screening efforts
Collaborate closely with colleagues inside and outside the DTA and in particular with Bioinformatic, Proteomic and medicinal chemist colleagues for data mining and screening deconvolution
Generate and interrogate cell-based models on mechanisms of resistance
Write procedures, reports, publications and other documents
Present experimental design and results internally and externally
This position is sponsored by the Roche Postdoctoral Fellowship Program and is initially limited to two years, a third year prolongation is possible.
Who you are
You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.
You are flexible, proactive, creative and detail-oriented, and have top teamwork competency but can also work highly independently. You have:
Recent PhD in Cancer Biology (max 4 years after completing PhD)
Strong background in Proteomics with hands-on expertise in Mass Spectrometry and relative data interpretation
Extensive hands-on experience with standard molecular biology methods including siRNA, shRNA, CRISPR/CAS9
Experience with basic assays to test oncology-relevant small molecules would be a plus
Innovative spirit with high degree of scientific engagement and desire to explore novel scientific and/or technical areas
Ability to work in a high-pace and dynamic scientific environment
Excellent organizational and analytical skills
Excellent inter-personal and communication skills / ability to build good working relations
Proven ability to present and publish research data