139 days ago on roche.com

Team Lead, Mechanistic & Cellular Enzymology, in Chemical Biology

Roche AG

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Team Lead, Mechanistic & Cellular Enzymology, in Chemical Biology

Team Lead, Mechanistic & Cellular Enzymology, in Chemical Biology

Switzerland, Basel-Town, Basel

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  • Job facts
The Chemical Biology Department is part of Therapeutic Modalities (TMo) within Roche Pharma Research and Early Development (pRED). We deliver leading edge science to drive the success of Roche’s early pipeline discovery research activities through strong expertise in high throughput or focused screening platforms, DNA encoded library technology, translational protein science & enzymology/biophysics, phenotypic cell-based screening and stem cell platforms, biostructure determination and computationally assisted drug discovery. Our breadth of capabilities further enable or drive innovative approaches across small, medium and large molecule therapeutic & drug delivery modalities.
The goal of this position is to provide the scientific leadership of a team responsible for the characterization, then leveraging of the detailed kinetic and chemical mechanism of enzyme drug targets, for the design of disease relevant Hit ID or Hit MoA/prioritization strategies and activities.  The team will also explore opportunities to leverage enzymology or enzymes as catalysts to enable or drive innovative approaches across small, medium and large molecule therapeutic & drug delivery modalities.
We are looking for a highly motivated scientific leader to join our team in Chemical Biology (CB) in the Roche Innovation Center Basel, Switzerland in order to expand and strengthen our efforts. Managing ~6 scientists with diverse expertise, including enzymology, mass spectroscopy, and biophysics, your responsibilities also include:
  • Develop & implement a team that characterizes enzyme mechanism (kinetic and chemical)- while ensuring mechanism(s) is leveraged for all Hit ID or Hit Qualification screening strategies,  wherever deemed valuable.
  • Contribute to the surveillance of the discovery portfolio, evaluating when mechanistic insights of an enzyme drug target, or the enzymology of pathways interrogated by phenotypic screens, may be of value to understand, and contribute to possible scientific strategies to that end.
  • Make “Translational Enzymology” a key capability in CB by coordinating with cellular biologists across the discovery & development organizations to link enzyme mechanistic insights to in-cell target engagement or binding kinetics/pharmacokinetics wherever possible.
  • Participate in a Hit Qualification Strategy team, together with CB lines and Med Chem: in the design of hit qualification best practices and strategies to prioritize compounds for start of chemistry.
  • Track record in Program Leadership: high level skills leading a drug discovery program to success, leveraging know-how & accountabilities from areas outside your own area of expertise and function
  • Seek & incubate internal & external technologies, methodologies or platforms that can better or faster characterize enzyme mechanism or compound MoA, including the exploration of opportunities to synergize across therapeutic modalities through leveraging enzymology or enzymes as catalysts.
  • Who you are
    You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.
    This position offers the unique opportunity to work in an interdisciplinary team in a leading pharmaceutical company. We expect outstanding motivation, creativity, analytical thinking and a strong scientific commitment. You have excellent scientific, interpersonal and communication skills with a track record in paying attention to the development of others, and scientists as leaders. You work very effectively and collaboratively in a highly matrixed, global organization. You will bring:
    • PhD (or relevant experience) in chemistry, biochemistry, enzymology, protein chemistry or biophysics with a strong background in the enzymology of drug discovery with > 5 years of industry experience
    • Well known and connected to industry and academia enzymology and/or biophysics experts and worldwide community; well published in the field of mechanistic enzymology or biophysics, and in the drug discovery of enzyme drug targets
    • Track record in solving enzyme kinetic and chemical mechanisms, ligand binding mechanisms, and using enzyme or binding mechanistic information to tailor drug discovery screening and screen follow up approaches; significant experience developing high-throughput assays for enzyme targets.
    • Track record of effectively leading a team of scientists with expertise across enzymology, analytics and biophysics.
    • Experience (track record preferred) in translating enzyme mechanism or binding kinetics to pharmacokinetics and other cellular contexts.
    • Track record developing or bringing in new enzyme screening assays, and methods/technologies that better or faster mechanistically characterize enzymes, ligand binding mechanisms and/or enhance/optimize the successful use of enzymes or enzymology in drug discovery.
  • Who we are
    Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites. Read more.

    Roche is an equal opportunity employer.
  • Job facts
    • Location Switzerland, Basel-Town, Basel
    • Function Research
    • Subfunction Biology
    • Schedule Full-time
    • Job level Team Leader
    • Job type Regular Employee
    • Division Roche Pharmaceuticals
    • Date 2016/06/08
    • Job-ID 3232071509
  • Get in touch
    Cristina Varela+41 61 687 25 27
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