138 days ago on roche.com

Section Head, Integrated Screening & Compound Logistics, in Chemical Biology

Roche AG

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Section Head, Integrated Screening & Compound Logistics, in Chemical Biology

Section Head, Integrated Screening & Compound Logistics, in Chemical Biology

Switzerland, Basel-Town, Basel

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  • Job facts
The Chemical Biology Department is part of Therapeutic Modalities (TMo) within Roche Pharma Research and Early Development (pRED). We deliver leading edge science to drive the success of Roche’s early pipeline discovery research activities through strong expertise in high throughput or focused screening platforms, DNA encoded library technology, translational protein science & enzymology/biophysics, phenotypic cell-based screening and stem cell platforms, biostructure determination and computationally assisted drug discovery. Our breadth of capabilities further enable or drive innovative approaches across small, medium and large molecule therapeutic & drug delivery modalities.
The goal of this position is to provide the scientific and operational leadership to drive the development and integration of multiple screening capabilities for small molecule Hit identification and follow-up screens qualifying hits for chemistry (Hit Qualification). With a focus on building this department as the preferred partner for Hit identification for therapeutic areas, this function will leverage diverse, flexible and state-of-the art screening and compound logistics platforms, from both internal and external capabilities, towards the goal of quickly providing multiple, qualified & disease-relevant starting points for chemistry per discovery program.
We are looking for a highly motivated scientific leader to join our team in Chemical Biology in the Roche Innovation Center Basel, Switzerland in order to expand and strengthen our efforts. Your responsibilities include:
  • Manage ~30 scientists with diverse expertise within cell biology, biochemistry, protein and cell assay development, screening & automation, DNA-encoded Library technologies, biophysics (LC/MS and SPR) and compound logistics.
  • Coordinate the running & integration of multiple screening platforms including HTS, DNA encoded Library screening, focused screening, fragment-based screening, and a Hit Qualification screening platform comprised of medium to high throughput biophysics screens (eg Mass Spectroscopy, SPR, Affinity Selection MS, etc.).
  • Participate in a leadership team which builds best practices and strategies for Hit Qualification work streams for all Hit ID programs, and ensure a Hit Qualification profiling strategy is in place for all programs before primary screening begins.
  • Orchestrate resourcing assignments with other department heads and external groups for all assay development & screening needs.
  • Seek & incubate via external partners, CROs or collaborations new screening technologies, assay methodologies or platforms that can better or faster integrate multiple screening platforms, or increase the speed, quality and diversity of discovering more disease relevant and tractable hits.
  • Maintain a cross-modality enterprise focus: Collaborate closely with internal and external colleagues in disease biology areas, translational pharmacology, medicinal chemistry, biologics discovery and RNA therapeutics to align priorities and explore opportunities to synergize and innovate especially through the leveraging of automation and screening practices.
  • Who you are
    You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.
    This position offers the unique opportunity to work in an interdisciplinary team in a leading pharmaceutical company. We expect outstanding motivation, creativity, analytical thinking and a strong scientific commitment. You have excellent scientific, interpersonal and communications skills with a track record in leadership and paying attention to the development of others, and scientists as leaders. You work very effectively and collaboratively in a highly matrixed, global organization. You bring:
    • PhD (or relevant experience) in chemistry, biology, biochemistry, enzymology, or biophysics with > 10 years of experience in running integrated high-throughput screening facility(ies).  
    • Well known, published and well connected to industry and academia experts and worldwide community in the field of early drug discovery (eg SLAS), and of platforms & technologies therein.
    • Track record in successfully overseeing and recommending to program teams: multiple, diverse & integrated Hit ID and Hit qualification screening platforms & strategies (in addition to conventional HTS). Includes working with cheminformatics teams on designing/implementing focused set screening strategies, and with biophysicist teams on running Hit Qualification assays.
    • Experience in leading teams who use insights from enzyme mechanistic information, binding kinetics and/or cellular disease biology to tailor Hit ID or Hit follow up screening formats or approaches. Includes the setting up of LC/MS, MoA/kinetics, structural modeling and/or biophysics/direct binding screens as standard processes for hit characterization & hit qualification.
    • Track record of continuously bench-marking internal screening and compound management processes, timings & technologies with industry standards & trends, and using Hit ID “dashboards” or other ways to define/track KPIs and continually track successes, understand failures, improve success rates.
    • Track record of externally facing leadership: through continuously assessing/optimizing balance of in-house vs externalized efforts, testing novel/new methodologies that could speed up and increase the quality of hit ID and Hit Qualification work streams or integrating external screening efforts into program workflows.
  • Who we are
    Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites. Read more.

    Roche is an equal opportunity employer.
  • Job facts
    • Location Switzerland, Basel-Town, Basel
    • Function Research
    • Subfunction Biology
    • Schedule Full-time
    • Job level Manager with Direct Reports
    • Job type Regular Employee
    • Division Roche Pharmaceuticals
    • Date 2016/06/21
    • Job-ID 3232947719
  • Get in touch
    Cristina Varela+41 61 687 25 27
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