Translational Medicine Leader - Immunology & Inflammation
Translational Medicine Leader - Immunology & Inflammation
Switzerland, Basel-Town, Basel
The Translational Medicine Leader (TML) is a core member of the Immunology and Inflammation Discovery & Translational Therapeutic Area (I&I DTA). The TML works in close collaboration with other TMLs and discovery scientists in the DTA and reports into the Head Translational Medicine in the DTA.
The TML role has significant impact and contributes to 3 major strategic areas: (i) early development strategy and delivery; (ii) translational discovery including target selection and biomarker discovery in an integrated discovery and development paradigm; and, (iii) identification and evaluation of external innovation opportunities.
The TML is accountable for the overall strategy and delivery of I&I programs from Clinical Candidate Selected (CCS) to Life Cycle Investment Point (LIP), e.g. progresses a project from discovery to readiness for phase III decision making comprises the most significant focus for the TML. As part of the overall program the TML defines the translational and biomarker strategy for his/her projects and is accountable for the delivery of all translational aspects required to drive exploratory and confirmatory development. As project leader the TML is accountable to deliver the overall project for pRED and the DTA which includes pre-clinical and clinical safety, regulatory, technical and business aspects. He/she will lead cross-functional teams with members of the DTA, pRED, Pharma Development and Global Product Strategy. The TML drives translational discovery activities for the DTA in close collaboration with discovery bench scientists to inform pathway and target selection and to identify predictive biomarkers which will inform early clinical development. Accessing external innovation is a core strategy of the DTA. Therefore, identifying opportunities to partner with leading academic institutions and accessing and internalizing external assets will be a core activity for the TML.
- Leads Immunology and Inflammation programs from entry into GLP toxicology to transition to late stage development
- Develops and implements effective project strategy with cross-functional pRED and Roche project team
- Develops target product profile (TPP) and criteria for transition to late stage development in collaboration with other pRED and Roche functions and is accountable for its delivery
- Defines translational medicine and biomarker strategy and delivers activities with subteam and key medical interfaces in Pharma Development, including Regulatory & Biostatistics
- Owns the exploratory CDP (e-CDP) for first-in-man (EIH), proof of mechanism (PoM) and proof of concept (PoC) studies and phase 2 LIP enabling studies
- Is accountable for Phase III-enabling activities, protocol synopses, study protocols, clinical study reports (CSRs) and related regulatory documents as well as overall design and the clinical and scientific content of experimental medicine
- Supports identification, assessment and internalization of external opportunities for the I & I DTA in collaboration with partnering and pRED functions
- Propose, establish and lead external collaborations to address strategic and tactical needs of DTA
- Works in close collaboration with I&I scientists and pRED functions to identify, select and validate targets of high relevance for I&I
- Develops translational discovery plan for new targets at entry into portfolio
Who you are
You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.
A physician scientist with an MD or MD/ PhD in a relevant field with proven record of scientific achievement as evidenced by presentations and publications in peer reviewed journals along with several years of independent experience in industry or academic settings are required.
- Demonstrated success in defining and implementing translational research direction that integrates mechanistic and clinical approaches
- Demonstrated translational research expertise in immunology/inflammation
- Demonstrated understanding of translational research tools, and ability to independently develop clinically relevant translational activities. Direct experience in clinical studies, biomarker discovery and development and use of imaging in experimental medicine highly desired
- Demonstrated ability to concurrently lead multiple programs/teams
- Understanding of the current unmet medical needs in the therapeutic area and able to think beyond current paradigms of care
- Collaboration comes naturally to you
- You thrive in a cross-functional matrix environment
- Entrepreneurial and viewing change as an opportunity rather than an obstacle
- Significant experience in pharmaceutical or drug development strongly desired; demonstrated track record of filing IND and providing clinical leadership to early stage development programs is a plus
Who we are
Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites. Read more.
Roche is an equal opportunity employer.
- Location Switzerland, Basel-Town, Basel
- Function Research
- Subfunction Early Development/ Translational Medicin
- Schedule Full-time
- Job level Manager without Direct Reports
- Job type Regular Employee
- Division Roche Pharmaceuticals
- Date 2015/04/07
- Job-ID 3092384507
Get in touch
D.Ferreira+41 61 688 21 90
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