228 days ago on roche.com

Lab Specialist - Ophthalmology

Roche AG

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Lab Specialist - Ophthalmology

Lab Specialist - Ophthalmology

Switzerland, Basel-Town, Basel

The Neuroscience, Ophthalmology and Rare Diseases (NORD) Translational Area (DTA) of Roche Pharmaceutical Research & Early Development (pRED) has an opening for a Lab Specialist within the Ophthalmology department located in Basel, Switzerland.  This group of over 30 Roche scientists is focused on the clinical translation of therapeutic approaches for eye diseases, including age related macular degeneration, diabetic retinopathy, and glaucoma.
We are seeking an exceptional, highly motivated, and talented Research Associate with demonstrated expertise in directly performing in vivo experiments using rodents.  This scientist will directly perform key experiments using established and emerging animal models of ocular disease to demonstrate efficacy of ocular therapeutics.
You will be a member of the Ophthalmology department and perform in vivo experiments in the laboratory to characterize disease mechanisms and pharmacology, using established imaging and other characterization technologies (ERG, OKT, OCT). They will correlate in vivo results with ex vivo and in vitro results using molecular biology techniques (protein and nucleic acid analysis) and histopathologic techniques on dissected ocular tissues. They will develop novel models of disease and establish novel imaging technologies and play a leading role in a team of associates, fellow scientists, and postdoctoral fellows, as a laboratory head. Work closely with internal and external collaborators within the Roche drug discovery community, such as chemistry, structural biology, screening, pharmaceutical sciences and safety pharmacology.
  • Coordinated interactions with external academic and contract research organizations will be part of the responsibility
  • They will inspire, train, and lead scientific talent, collaborators and colleagues
  • Play a key role in improving infrastructure (internal, external) through training of scientists in appropriate in vivo methodologies, and acquisition and or maintenance of in vivo equipment
  • Participate in scientific diligence to evaluate opportunities for external innovation.
  • Coordinate animal breeding, maintain and acquire animal licenses including interactions with the local authority
  • Present the laboratory’s scientific progress to internal stakeholders as well as the external academic and drug discovery community through presentations and publications
  • Who you are
    You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.
    We are looking for a passionate and accomplished Associate with a BS/MS or apprenticeship and approximately 8 years’ experience within academia and/or the biotechnology and biopharmaceutical industries, with demonstrated expertise in the following areas: retinal imaging, ocular surgical interventions, ocular animal model development and characterization (in vivo and ex vivo), and in vitro ocular disease models.
    • Long standing proficiency in veterinary ophthalmology, ocular imaging of animal models of disease, and evaluation of ocular drug delivery systems in animal models
    • Proficiency with intraocular injections (intravitreal, subretinal, anterior chamber, subconjunctival), histopathologic characterization of ocular tissues, ocular imaging using OCT, SLO, and/or fundoscopic instruments, ERGs and optokinetic tracking (OKT) technology
    • Extensive experience with cell culture and ocular tissue dissection and preparation, confocal microscopy of tissues and cells, and image analysis to score pathologic features
    • Hands on experience of the following rodent models of ocular disease: diabetic retinopathy (STZ), laser induced choroidal neovascularization, ischemia-reperfusion, oxygen-induced retinopathy (OIR), acute hyperpermeability and inflammatory challenges
    • Experience with vitreous flurophotometry (e.g. Fluorotron Master) and  ocular fluid sampling (aqueous humor, vitreous humor, tear film)
    • Capability to train a team of scientists on the above methods
    • Ability to formulate and implement innovate scientific strategy and lab operations, and to champion ideas and projects; independent thinker
    • Willingness and ability to build and embrace internal, external relations, collaborations and partnerships
    • Excellent communication skills, oral and written
  • Who we are
    Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites. Read more.

    Roche is an equal opportunity employer.
  • Job facts
    • Location Switzerland, Basel-Town, Basel
    • Function Research
    • Subfunction Biology
    • Schedule Full-time
    • Job level Individual Contributor
    • Job type Regular Employee
    • Division Roche Pharmaceuticals
    • Posted since 2016/07/13
    • Job-ID 3232317715
  • Get in touch
    D. Ferreira +41 61 688 2190