134 days ago on roche.com

Lab head High-throughput Mass Spectrometry, in Chemical Biology

Roche AG

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Lab head High-throughput Mass Spectrometry, in Chemical Biology

Lab head: High-throughput Mass Spectrometry, in Chemical Biology

Switzerland, Basel-Town, Basel

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  • Job facts
The Chemical Biology Department is part of Therapeutic Modalities (TMo) within Roche Pharma Research and Early Development (pRED). We deliver leading edge science to drive the success of Roche’s early pipeline discovery research activities through strong expertise in high throughput or focused screening platforms, DNA encoded library technology, translational protein science & enzymology/biophysics, phenotypic cell-based screening and stem cell platforms, biostructure determination and computationally assisted drug discovery. Our breadth of capabilities further enable or drive innovative approaches across small, medium and large molecule therapeutic & drug delivery modalities.
This Lab head position will lead the development of low- to high- throughput biophysical Hit Qualification screening platforms as a core capability in the small molecule drug discovery enterprise at Roche. Focusing your expertise in Mass Spectroscopy on the development of high throughput LC/MS screening as a standard screening or profiling platform, the position integrates the use of several biophysical label free or direct binding screening platforms across the Hit ID and Hit Qualification work streams, towards the goal of providing multiple, qualified & novel starting points for chemistry per discovery program.
We are looking for a highly motivated PhD level scientist to join our team in Chemical Biology (CB) in the Roche Innovation Center Basel, Switzerland in order to expand and strengthen our efforts. Your responsibilities include:
  • Depending on level of experience- you may manage 1-4 scientists with diverse expertise within assay development, automation screening science, LC/MS and SPR or other biophysical assays.
  • Develop LC/MS as a bona fide Hit Qualification screening platform at Roche, and oversee the development of low to high-throughput biophysics screening platform(s) in general, as part of Hit Qualification or focused screening work streams in Chemical Biology (Rapid Fire LC/MS; SPR; etc.).
  • Serve as a “screening coordinator” across the Chemical Biology department, and depending on your experience, you may also manage, run or oversee diverse screening campaigns including HTS, focused screening, fragment-based screening in addition to hit qualification profiling.
  • Work with other Biophysics and LC/MS teams across the department and R&D to coordinate/prioritize work that enables assay development, binding/activity or enzyme mechanistic understanding, SAR, Structural studies or translation of compound activities in the cell.
  • Work with the internal and external biophysics and mass spectroscopy communities to enable innovation in & evolution of instrumentation and methodologies.
  • Contribute to the Hit Qualification Strategy team, together with CB lines and Med Chem in the design of hit qualification best practices and strategies in place to prioritize compounds for start of chemistry.
  • Who you are
    You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.
    This position offers the unique opportunity to work in an interdisciplinary team in a leading pharmaceutical company. We expect outstanding motivation, creativity, analytical thinking and a strong scientific commitment. You have excellent scientific, interpersonal and communications skills and you work very effectively and collaboratively in a highly matrixed, global organization.
    • PhD (or relevant experience) in chemistry, biochemistry, enzymology, protein chemistry or biophysics with an expertise in Mass Spectroscopy, with > 5 years of drug discovery experience.
    • Expertise in Mass Spectroscopy and externally visible, well published and well connected to the Mass Spectroscopy (and Drug Discovery) communities.
    • Experience preferred in HTS assay development, compound screening (beyond MS-based screens), and in assessing in-cell activities via Mass Spectroscopy analyses of cell or tissue samples.
    • Experience preferred in managing or leading scientists or a team.
    • Experience preferred in Program Leadership: high level skills leading a drug discovery program to success, effectively leveraging know-how & accountabilities from areas outside your own area of expertise and function.
    • Experience working in new directions, building new platforms or bringing in new methods/technologies in mass spectroscopy and biophysics.
  • Who we are
    Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites. Read more.

    Roche is an equal opportunity employer.
  • Job facts
    • Location Switzerland, Basel-Town, Basel
    • Function Research
    • Subfunction Chemistry
    • Schedule Full-time
    • Job level Team Leader
    • Job type Regular Employee
    • Division Roche Pharmaceuticals
    • Date 2016/08/26
    • Job-ID 3233192309
  • Get in touch
    Cristina Varela+41 61 687 25 27
    Work place: Basel
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