244 days ago on emploi.epfl.ch

PhD position microscopy LBP

EPFL - Ecole Polytechnique Fédérale de Lausanne

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PhD position microscopy LBP

PhD position microscopy LBP

Nonlinear Imaging of Membranes and Potentials

A PhD student position is available at the Laboratory for fundamental BioPhotonics (LBP) at the École Polytechnique Fédérale de Lausanne (EPFL), Switzerland.

The electrostatic properties of membranes are crucial for the functioning of living systems. Neurons produce potentials that enable us to think, learn and act. On the molecular level these potentials are highly dependent on the precise molecular composition and structure of membranes that are composed of lipids, proteins, water and ions. In addition, the membrane potential landscape is confined on an interface that is less than 5 nm thick. Changes occur on time scales on the order of milliseconds.

What are the underlying molecular mechanisms behind the occurrence and distribution of membrane potentials? What is the role of water? How does a membrane composed of lipids and proteins respond to currents on a molecular level? Can we observe them label-free in time and space?

The Project
Nonlinear optical imaging and spectroscopic techniques have a great potential for label-free imaging of the 3D distributions of molecular species and electrostatic potentials on membrane interfaces. The aim of the project is to further develop spectroscopic and imaging methods in conjunction with electrophysiological recordings to enable the spatial and temporal mapping of the surface potential by optical means. Using these methods, the above questions can be answered.

The Candidate
We are looking for a highly motivated candidate with a background in photonics, physics, chemistry or electrical engineering, with experience in nonlinear optics / microscopy. We offer excellent working conditions and a state-of-the-art infrastructure in a highly dynamic and international environment at the forefront of research.

Place of work: Lausanne

The Application Procedure
Applications should include a motivation letter, detailed CV, transcripts of diplomas as well as three letters of reference. In conjunction to the application the candidate should apply to one of the photonics doctoral school (http://phd.epfl.ch/page-19793-en.html).

For Applications / Information
Prof. Sylvie Roke
Julia Jacobi chair in photomedicine
Laboratory for fundamental BioPhotonics (LBP)
Ecole Polytechnique Federale Lausanne (EPFL)
Institute of Bio-engineering (IBI), School of Engineering (STI)
BM 4112
Station 17
CH-1015 Lausanne, Switzerland
Phone: + 41 21 693 1191
E-Mail: sylvie.roke@epfl.ch
WWW: http://lbp.epfl.ch