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Postdoctoral Position Epigenetic and Transcriptional Mechanisms of Brain Map Formation

Friedrich Miescher Institute for Biomedical Research

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Postdoctoral Position Epigenetic and Transcriptional Mechanisms of Brain Map Formation

Postdoctoral Position: Epigenetic and Transcriptional Mechanisms of Brain Map Formation

A postdoctoral position is immediately available in the group of Prof. Filippo Rijliat the Friedrich Miescher Institute for Biomedical Research (FMI). We apply a multidisciplinary experimental approach to investigate the epigenetic and transcriptional mechanisms of topographic circuit formation in the mouse brainstem. Current work addresses the in vivo regulation of the coordinated expression of Hox transcription factors in specific subsets of progenitors and neurons during migration and connectivity. Moreover, we are studying the functional role of selected epigenetic regulators. To this aim, we use ad hoc mouse genetic tools, imaging of fluorescently labeled neurons and axonal tracts, trans-synaptic viral tracing of defined subpopulations, in utero electroporation, molecular phenotype analysis of strains carrying specific mutations, and some behavioral readouts (Oury et al., Science2006; Geisen et al., PLoS Biol2008; Vitobello et al., Dev Cell2011; Di Meglio et al., Science2013; Bechara et al., Cell Reports2015).

The proposed projectaims at bridging neuronal circuit development and epigenetics and focuses on the regulation of neuronal identity and plasticity during topographic circuit assembly. The relay of sensory information from the external world is achieved through the assembly of topographic connectivity maps. However, the mechanisms allowing coordinated gene transcription underlying the establishment of point-to-point connectivity are still poorly understood. We are currently interested in mapping chromatin states in identified neuronal subsets during circuit formation. Available project(s) will focus on uncovering the epigenetic signature and regulation of neuronal enhancers involved in the development of trigeminal (whisker-to-barrel) and corticocerebellar somatosensory circuits in the mouse.

The successful candidateis interested in these topics and holds a recent PhD with significant expertise in chromatin analysis approaches (e.g. ChIP-seq, ATAC-Seq, 4C-seq). Candidates with strong backgrounds in molecular and/or functional aspects of circuit formation will also be considered. The position is funded for an initial period of 2 years, with the possibility of extension. A competitive salary and access to state-of-the-art research facilities will be provided.

The FMI, affiliated with the University of Basel and the Novartis Institutes for Biomedical Research, is an international institute pursuing fundamental research (www.fmi.ch). It has a staff of 340 including about 200 postdoctoral fellows and graduate students. The FMI is situated in Basel, Switzerland, a city in the center of Europe offering an outstanding scientific and cultural environment.

Applicationsshould be emailed to filippo.rijli@fmi.chand include a motivation letter, CV and names and email addresses of at least two referees.

Prof. Filippo Rijli

Friedrich Miescher Institute for Biomedical Research