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A postdoctoral position is available in the group of Prof. Patrick Matthiasat the Friedrich Miescher Institute for Biomedical Research in Basel, Switzerland, to study the role of the deacetylase HDAC6 and related proteins in viral infection.
Our labhas a long-standing interest in understanding the biological roles of Histone Deacetylases (HDACs), enzymes which are of high medical relevance in diverse settings (e.g. Kwon et al., G&D, 2007; Zhang et al., MCB 2008; Yamaguchi et al., G&D 2010; Jacob et al., Nat Neurosci 2011; Scholz et al, Nat Biotech 2015; Miyake et al., Nat Chem Biol, 2016). We have recently identified an unexpected novel role for HDAC6 and ubiquitin in infection by influenza virus: in this case, HDAC6, by interacting with ubiquitin and motor proteins forms the basis of a molecular module that helps viral uncoating and facilitates infection (Banerjee et al., Science 2014).
Funded by the Swiss initiative for Systems Biology (SystemsX.ch), the VirX projectfollows a multi-disciplinary approach and brings together several labs with complementary expertise in virology, protein acetylation/deacetylation, biochemistry, structural biology and mathematical analysis. The overall aim of the VirX consortium is to expand these initial observations to get a detailed understanding of the role of the HDAC6/Ubiquitin module for infection by influenza and other viruses. This will include a diverse set of experimental techniques such as molecular and structural studies, cell biological analysis, transgenic mouse work, shRNA screenings and mathematical modeling.
The project at the FMIwill in particular focus on understanding the formation and regulation of the HDAC6/Ubiquitin module, identifying putative modulators, testing other viruses and analyzing in vivo outcomes in mice that have been engineered to alter the pathway.
The position requirestraining in virology, with a strong background in molecular biology and/or biochemistry; additional expertise in cell biology and/or in vivo work is a plus. The candidates should have a demonstrated publication record, be highly self-motivated and work well in a team as well as an individual contributor.
The FMIis an international institute devoted to fundamental biomedical research aimed at understanding the basic molecular mechanisms of health and disease. The FMI offers a highly stimulating working environment with access to cutting-edge core facilities.
Applications should be submitted electronically at www.fmi.ch/opening
and include your motivation letter with a brief statement of research objectives, your resume with list of publications, and contact details for at least 2 referees.
Review of applications will begin immediately. Submissions is open until September 25th, 2016, or until the position is filled.
For further information please contact Patrick Matthias firstname.lastname@example.org.