108 days ago on acimmune.com

Research Scientist (RS2)

AC Immune SA

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Research Scientist (RS2)

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Research Scientist


Function Research Scientist

Location / Contact EPFL Innovation Park, Building B, 1015 Lausanne

Percentage 100%. Available immediately

Overview AC Immune is a Swiss Biotechnology company specialized in the
development of innovative therapies against Alzheimer’s disease and other
neurodegenerative disorders. AC Immune is seeking a highly qualified
Research Scientist to expand the company’s efforts in research. The
candidate must possess scientific background in structural biophysics and
protein dynamics in neurodegenerative diseases and a clear record of
accomplishment in an academic or a commercial setting. S/he must have
demonstrated their ability to make significant discoveries in an academic
setting or bring a research product to a clinical stage. Promising
opportunities for growth and advancement exist.

Job description • Provides hands-on research support for the Biology research team within
the Biology department working on the discovery and characterization of
PET radiotracers for the diagnosis of neurodegenerative disorders
• Preparation and characterization of human brain tissue for binding studies
• Evaluation of new procedures and protocols for the enrichment of
pathological protein aggregates from human tissues (e.g.
immunoprecipitation, sucrose gradient, FACS)
• Optimization of binding assays or other quantitative assays for Kd and Ki
• Setting up autoradiography assay conditions for new radioligands on
human and TG mouse tissue sections
• Screening small molecule compounds that are regularly synthesized by the
Chemistry team using new as well as established assays
• Immunostaining of human tissue sections
• Evaluating target engagement of compounds by direct staining on tissue
• Autoradiography with tritiated ligands

Qualifications The candidate should have the following qualifications:

• Ph.D. training in life sciences
• Previous experience in structural biophysics and protein dynamics
• Previous experience in neuroscience and neurodegenerative disorders,
notably ALS and FTD along with TDP-43, is an advantage
• Postdoctoral experience is an advantage
• Excellent organizational skills and capability of data documentation
• Team spirit paired with autonomous and rigorous work style
• Excellent oral and written skills in English is mandatory