70 days ago on acimmune.com

Research Scientist (RS2)

AC Immune SA

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Research Scientist (RS2)

Page 1 of 1

Research Scientist


Function Research Scientist

Location / Contact EPFL Innovation Park, Building B, 1015 Lausanne


Percentage 100%. Available immediately

Overview AC Immune is a Swiss Biotechnology company specialized in the

development of innovative therapies against Alzheimer’s disease and other

neurodegenerative disorders. AC Immune is seeking a highly qualified

Research Scientist to expand the company’s efforts in research. The

candidate must possess scientific background in structural biophysics and

protein dynamics in neurodegenerative diseases and a clear record of

accomplishment in an academic or a commercial setting. S/he must have

demonstrated their ability to make significant discoveries in an academic

setting or bring a research product to a clinical stage. Promising

opportunities for growth and advancement exist.

Job description • Provides hands-on research support for the Biology research team within

the Biology department working on the discovery and characterization of

PET radiotracers for the diagnosis of neurodegenerative disorders

• Preparation and characterization of human brain tissue for binding studies

• Evaluation of new procedures and protocols for the enrichment of

pathological protein aggregates from human tissues (e.g.

immunoprecipitation, sucrose gradient, FACS)

• Optimization of binding assays or other quantitative assays for Kd and Ki


• Setting up autoradiography assay conditions for new radioligands on

human and TG mouse tissue sections

• Screening small molecule compounds that are regularly synthesized by the

Chemistry team using new as well as established assays

• Immunostaining of human tissue sections

• Evaluating target engagement of compounds by direct staining on tissue


• Autoradiography with tritiated ligands

Qualifications The candidate should have the following qualifications:

• Ph.D. training in life sciences

• Previous experience in structural biophysics and protein dynamics

• Previous experience in neuroscience and neurodegenerative disorders,

notably ALS and FTD along with TDP-43, is an advantage

• Postdoctoral experience is an advantage

• Excellent organizational skills and capability of data documentation

• Team spirit paired with autonomous and rigorous work style

• Excellent oral and written skills in English is mandatory