87 days ago on nccr-rna-and-disease.ch

Other open positions related to RNA and Disease

Swiss National Center of Competence in Research RNA & Disease

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Other open positions related to RNA and Disease

Post-doctoral position at ENS-Lyon (France) – Chromatin architecture and RNA splicing

A post-doctoral position is available in the thriving city of Lyon (France) to study the molecular mechanisms by
which RNA helicases control the epigenome and its 3-dimensional organization to ensure cell type specific
programs of gene expression, with a focus on RNA splicing.

The Laboratory of Biology and Modeling of the Cell (LBMC) of ENS-Lyon hosts a dozen of internationally
competitive teams that investigate the molecular basis of major cellular functions, using a variety of cellular and
organism experimental models, and giving a strong priority to biocomputing approaches. The LBMC is well
equipped and is located on a dynamic research campus with all required state-of-the-art technological facilities.
Lyon is the 2nd research and higher education center in France, and it offers a great diversity of work
opportunities. It is well connected to major european cities (and beyond) by high-speed train lines and over 100
direct flight connections worldwide. Classed a UNESCO World Heritage Site, and considered as the french capital
of gastronomy, Lyon has a rich artistic and cultural offer, but it is also a modern and dynamic city which offers a
vibrant quality of life.

The team “Alternative splicing and the plasticity of the cancer cell”, headed by Didier Auboeuf, is
internationally recognized for its expertise in high-throughput analyses of gene expression (especially RNA
splicing) and for its overall contribution to our knowledge about gene expression regulation in mammals. It is
well funded (major grants from ANR, INCa, Fondation ARC…) and is composed of a dozen of people (wet lab
biologists and bio-informaticians), including 3 permanent scientists.

The candidate will investigate the connections between the epigenome, the 3D architecture of chromatin and
the regulation of gene expression (especially alternative splicing) in cancer cells and/or in the context of cell
differentiation. He/she will focus on the function of RNA helicases in this cross-talk, by integrating data obtained
from high-throughput approaches and molecular and cellular biology experiments.
Candidates must be motivated by fundamental biological questions and eager to interact with people with
different backgrounds (biologists and bioinformaticians). Candidates with strong skills in molecular biology
including gene transcription and splicing, epigenetics, chromatin biology and/or functional genomics, are warmly
encouraged to apply. Competences in bio-informatics analyses (ChIPseq, RNAseq…) would be advantageous but
are not a prerequisite.
The position is funded on a principle of 2+1 years. Recruitment opportunities by french academic research
organizations may be discussed depending on the goals and qualification of the selected candidate.

Recent publications

  • Bourgeois, Mortreux and Auboeuf D. (2016). The multiple functions of RNA helicases as drivers and switchers of the genetic information flow. Nature Rev. Mol. Cell Biol. 17:426–438
  • Dardenne et al. (2014). RNA Helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation. Cell Rep. 7:1900-13.
  • Mallinjoud et al. (2014). Endothelial, epithelial and fibroblast cells exhibit specific splicing programs independently of their
    tissue of origin. Genome Res. 24:511-21.

Please send a cover letter, your CV and the names of 2-3 references to :

Cyril Bourgeois (cyril.bourgeois@inserm.fr)