90 days ago on roche.com

Lab Specialist, Single cell genomics in Neurodegeneration (12 months)

Roche AG

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Lab Specialist, Single cell genomics in Neurodegeneration (12 months)

Lab Specialist, Single cell genomics in Neurodegeneration (12 months)

Switzerland, Basel-Town, Basel

The Neuroscience discovery group is involved in research and development of novel therapies for diseases such as autism, schizophrenia, multiple sclerosis and Alzheimer’s disease. We are a state-of-the-art human genetics and genomics lab located in the Neuroscience discovery department at F.Hoffmann La-Roche, Basel, Switzerland and are hiring a Lab Specialist.

 

Our research centers on the study of human genetics and genomics of neuropsychiatric, neurodevelopmental and neurodegenerative diseases to identify genes and causal molecular pathways. The main goal of the lab is to identify and validate new drug targets using integrative genomic approaches. We aim to understand genetic, molecular and cellular mechanisms by which disease associated mutations (both common and rare) influence disease risk.

 

We study i) gene/isoform expression in post mortem human brain tissues and cell types from diseased and normal healthy subjects , ii) pharmacogenomics of drug response and iii)  genotype- phenotype relationship through large scale genome sequencing and clinical phenotyping efforts. We work closely with our neuroscience colleagues to help them use this molecular information to target specific neural circuits in disease relevant model systems both in vitro and in vivo. We integrate multiple genomics data sets including RNA seq, Chipseq, single cell transcriptomics, long read transcript sequencing and whole genome sequencing to address these questions.

 

  • Conducting experiments with mouse, rat and post mortem human brain tissue specimens to optimize protocols for single cell and single nuclei RNAseq.
  • Preparing libraries for single cell RNAseq and long read sequencing
  • Analyzing data and presenting findings in team meetings


  • Who you are
    You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.
    You have a BS/MS certified course in human molecular genetics, medical genetics or  molecular biology.
     
    • Strong knowledge in the areas of molecular biology and RNA-sequencing
    • Good hand on experience in i) mouse/rat brain dissections, ii) preparing RNA sequencing libraries for short read and long read RNA sequencing
    • Good track record of scientific achievement (publications in peer reviewed journals)
    • Strong team player with excellent communication skills, attention to detail, and the desire to work in a fast-paced, cutting-edge environment
    • Highly motivated to work in a multicultural team with a great interest in acquiring novel techniques and gaining scientific knowledge
    • Fluent in English (writing and speaking)

     

  • Who we are
    Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites. Read more.

    Roche is an equal opportunity employer.
  • Job facts
    • Location Switzerland, Basel-Town, Basel
    • Function Research
    • Subfunction Other Research
    • Schedule Full-time
    • Job level Individual Contributor
    • Job type Regular Employee
    • Division Roche Pharmaceuticals
    • Posted since 2017/09/14
    • Job-ID 3421003205