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Roche Postdoctoral Research Fellow - Using State-of-the-art Bioengineering to develop a Blood Brain Barrier Model (temporary, 2 years)

Roche AG

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Roche Postdoctoral Research Fellow - Using State-of-the-art Bioengineering to develop a Blood Brain Barrier Model (temporary, 2 years)

Roche Postdoctoral Research Fellow - Using State-of-the-art Bioengineering to develop a Blood Brain Barrier Model (temporary, 2 years)

Switzerland, Basel-Town, Basel

The blood brain barrier (BBB) or the complete neurovascular unit (NVU) is a key component of the communication between the central nervous system (CNS) and the rest of the body. The BBB regulate this communication in a highly sophisticated way and thus is also involved in many brain disorders.

 

As a Postdoctoral Fellow in the Department of Neuroscience Discovery and Chemical Biology you will focus on a research project aiming at recapitulating the brain NVU in vitro using state-of-the-art bioengineering combining microfluidics and stem cell technology. The model will include all cell types in an attempt to allow the natural cell-cell communication and arrangement. Our mission is to use it to study transport of large molecules across the BBB, understanding trafficking and cellular sorting of different biological constructs.

 

The Roche Postdoctoral Fellowship (RPF) program is aimed at supporting excellent young scientists focusing on collaborative R&D projects between Roche and international academic institutions. Both internal Roche and academic experts will mentor you, and you will have the potential to perform hands on research in both lab environments.

 

The partnership with academia is an important aspect of our program's approach. This two-year postdoctoral project will be based at the Roche Innovation Centre Basel, Switzerland and you will benefit from the collaboration with a leading academic lab at University of California, San Diego.

This position is sponsored by the RPF Program and is initially set for two years, with the possibility of extension for a third year. Your responsibilities include:

  • Working to significantly contribute to our understanding of brain delivery of biologics for brain disorders and the mechanism by which large molecule can cross the BBB;
  • Investigating how this technology can be refined into a more efficient transport technology;
  • Using this approach to provide a much more robust model currently available to translate and predict in vivo properties.
  • Who you are
    You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

    To be successful in this role, you have a recent PhD in Neuroscience with a great scientific record and at least one first author publication in a peer-reviewed journal. In addition you have/are:

     

    • Strong expertise in iPSC-based in vitro modeling (desirable);
    • Background in BBB research or vascular biology (preferable);
    • Antibody engineering background (valuable);
    • Experience with microfluidic device and high-resolution microscopy like confocal is a big plus;
    • Flexible, creative, and detail-oriented with a can-do attitude.

     

    Please submit your application including a CV, a list of publications, a letter of motivation and 2 letters of reference.

  • Who we are
    Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites. Read more.

    Roche is an equal opportunity employer.
  • Job facts
    • Location Switzerland, Basel-Town, Basel
    • Function Research
    • Subfunction Other Research
    • Schedule Full-time
    • Job level Entry Level
    • Job type Temporary Employee
    • Division Roche Pharmaceuticals
    • Posted since 2017/11/22
    • Job-ID 3427253853
  • Get in touch
    Luanda De Sa Pereira +41 61 687 88 84