52 days ago on roche.com

Team leader, in vitro tissue and disease modeling

Roche AG

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Team leader, in vitro tissue and disease modeling

Team leader, in vitro tissue and disease modeling

Switzerland, Basel-Town, Basel

In this role,.you will be part of a team of scientists that uses human-relevant in vitro systems and innovative readouts to accelerate and improve the drug development process while reducing the need for animal testing. As a highly motivated and engaged senior scientist you will be dedicated to the development and application of advanced cellular systems, including immune-competent tissue models, and will participate in the early profiling of drug candidates across disease areas. Particularly, you will focus on combining 3D multi-cellular cultures, organs-on-a-chip/microphysiological systems,immunophenotyping and confocal imaging technologies to study the mode of action and predict potential liabilities of novel molecules. Furthermore you will:

  • Lead a group of scientists and associates dedicated to the implementation and application of advanced cellular models and molecular approaches for mechanistic safety studies
  • Elaborate the group’s strategy, develop innovative concepts to support complex drug development programs by use of novel in vitro tools, supervise laboratory activities, experimental design, results interpretation
  • Liaise to safety project leaders and expert disease biologists (immuno-oncology, inflammation and immunity) to support discovery and development projects with customized solutions addressing key safety questions
  • Play key lead role in team’s microphysiological systems/organ on a chip efforts: Research plan and strategy, supervision of external & internal activities
  • Define workable concepts for implementation of novel tools to support portfolio
  • Engage in strategic discussions with internal stakeholders on pathways to use MPS as integrated pharmacology/toxicology model during pre-clinical development

  • Who you are
    You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

    You are a PhD Mol/Cell Biology, MD or equivalent, several years of experience in relevant field (academia and/or industry) with proven track record (publications. In addition, you have:

    • Expert scientist level in cell biology with good knowledge in immunology; expertise with advanced cell models, microphysiological systems and cell engineering techniques; experience in drug development is a plus
    • Excellent communication skills, strong innovative potential, be key driver moving new tools into application

  • Who we are
    Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites. Read more.

    Roche is an equal opportunity employer.
  • Job facts
    • Location Switzerland, Basel-Town, Basel
    • Function Research
    • Subfunction Toxicology / Preclinical Safety / Pathol
    • Schedule Full-time
    • Job level Team Leader
    • Job type Regular Employee
    • Division Roche Pharmaceuticals
    • Posted since 2017/10/23
    • Job-ID 3425661511
  • Get in touch
    Sabine Wehren +41616888462