Please refer to JobSuchmaschine in your application
Switzerland, Basel-Town, Basel
The Neuroscience discovery group is involved in discovery, research and development of novel therapies for diseases with high unmet medical need such as schizophrenia, multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease. The RiSE program (Roche Internships for Scientific Exchange) offers the most talented postgraduate students the opportunity to enhance their competencies and to gain valuable work experience with us.
The Neurodegeneration / Regeneration and Neuroimmunology Sections within Neuroscience Discovery are located in Basel, Switzerland. The research teams employ in vivo, human neuronal cell culture and biochemical methods to explore pathomechanisms related to neurodegenerative diseases and perform discovery work for novel targets and biomarkers. The area of particular interest for this project is to study lysosomal dysfunction in Parkinson’s disease (PD). GBA(glucocerbrosidase)-associated neurodegeneration is the most common known genetic risk factor for several Lewy body disorders. Furthermore there is an inverse correlation between glucocerebrosidase protein/activity and α-synuclein in the substantia nigra, however the molecular basis for this reciprocal relationship remains elusive.
To this end, the project is aimed at addressing the pathomechanism in human tissue derived from both PD GBA mutation carriers and idiopathic PD, focusing on lysosomal pathways and functions. Furthermore, the project will involve identifying abnormal interactors of glucocerbrosidase in PD (synuclein pathology) versus aged match control brains. Appropriate cellular model systems are available and shall be used assess effects of tools compounds/reagents on the lysosmal system. Ultimately, the elucidation of lysosomal patho-mechanisms will guide development of therapeutics for Lewy body disorders.
During the internship your tasks will include:
Moreover you are/have:
The internship can start in March 2017 or upon availability – please clearly indicate your preferred starting date of internship on your motivation letter.
Applications need to include a CV and a cover letter, as well as a letter from your academic supervisor supporting your RiSE application.
Please note that non-EU/EFTA nationals have to successfully apply for a Swiss work permit. We would like to point out, that a pre-recorded video interview can be the first selection step, if your application is considered as a fit with our expectations for this internship