123 days ago on roche.com

Biomarker Experimental Medicine Leader (BEML) - Ophthalmology

Roche AG

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Biomarker Experimental Medicine Leader (BEML) - Ophthalmology

Biomarker Experimental Medicine Leader (BEML) - Ophthalmology

Switzerland, Basel-Town, Basel

The Biomarker Experimental Medicine Leader (BEML) – Ophthalmology, will be accountable for developing and delivering molecular and imaging biomarker strategies within NORD in particular Ophthalmology. This includes enabling testing of biological and clinical hypothesis, including methods for establishing target engagement, Pharmaco-dynamic responses, patient selection and stratification and measuring disease progression.

 

The remit includes programs from late preclinical through Phase 3 and preparation for market authorization and filing. You will develop therapeutic area biomarker strategy and contribute to therapeutic strategy of Ophthalmology and Lead biomarker subteams and be a member of clinical and project teams as applicable.

You will be accountable for molecular and imaging biomarker data in trials involving blood- and Aqueous humour-based assays, ensuring standardization of methodologies across sites and countries, highest data QC, monitoring of sites and CROs, and protocol compliance

  • Guide diagnostic biomarker development and PHC strategy
  • Design, edit, write and review protocols and study reports for experimental medicine and clinical pharmacology studies from early proof-of-concept through global Phase III
  • Work with statisticians on analysis plans involving molecular and imaging biomarker endpoints.
  • Liaise closely with cross-functional study team members, providing expert input on data review and interpretation
  • Explore and develop novel opportunities to integrate biomarker studies into late stage development
  • Publish data in top-tier journals, attend and present at international meetings

 

  • Who you are
    You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

    A PhD or MD with strong focus on the application of Ophthalmology biomarkers in clinical development and disease understanding is required along with at least 5 years post-doc experience in molecular and imaging biomarker research, ideally including relevant practical experience in pre-clinical or clinical image analysis in ophthalmology. In depth understanding and practical expertise in the development of molecular assays and data review is needed.

     

    Your capacity to work effectively in multidisciplinary teams, proactive attitude, problem-solving capacity and ability to work independently is required. Collaborative experience in pharmaceutical/biotechnology industry-based research, including expert knowledge of data acquisition and analysis within large-scale multi-center trials. Strong international network in biomarker research, and including representation in pre-competitive consortia.

    • Strong publication record
    • Strong influencing skills: proven abilities to get things done without formal authority
    • Outstanding organizational & time management skills: proven abilities to manage multiple, often complex and sometimes competing, objectives, goals and other priorities to effective and efficient conclusion
    • Excellent oral and written communication skills in English are required

     

     

     

     

     

     

     

  • Who we are
    Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites. Read more.

    Roche is an equal opportunity employer.
  • Job facts
    • Location Switzerland, Basel-Town, Basel
    • Function Research
    • Subfunction Early Development/ Translational Medicin
    • Schedule Full-time
    • Job level Individual Contributor
    • Job type Regular Employee
    • Division Roche Pharmaceuticals
    • Posted since 2017/08/10
    • Job-ID 3412184258
  • Get in touch
    Darren Ferreira +41 61 688 21 90