Please refer to JobSuchmaschine in your application
Job ID 214042BR Position Title Computational Chemist Division Global Drug Development Business Unit TECHNICAL R & D GDD Country Switzerland Work Location Basel Company/Legal Entity Novartis Pharma AG Functional Area Research & Development Job Type Full Time Employment Type Regular Job Description In this position you will work in a state-of-the-art Solid State Chemistry group that incorporates in silico computational modelling tools into the early stage physical form selection process, an integral phase in the drug development cycle. You will work in an interdisciplinary team, generating and interpreting data from modelling/computational simulations and liaising with experimentalists to provide information and knowledge that enables, for example, the systematic modification of crystallization parameters, the control of polymorphism, advancement of physical form selection, and modification of the crystal habit of small organic molecules, specifically active pharmaceutical ingredients (APIs). Through combining an advanced knowledge of various computational and modelling approaches with crystal chemistry, and the drug development process, you would aid in identifying, prioritizing and progressing the most suitable physical forms. The position requires a strong focus on scientific excellence in the area of computational chemistry as well as being able to extract and analyze decision making data associated with the crystal structure of the API to build predictive models based on such information for subsequent verification in a chemistry laboratory.
The position involves close collaboration with internal and external scientists from various disciplines, and cross-functional interactions within technical project teams, broadly covering the chemical, formulation and computational arenas.
Ideally you possess:
- A strong background in applying molecular and/or quantum mechanical modelling tools to small organic molecules for the purpose of modifying and optimizing their solid state properties (e.g. crystal habit, stability, solubility)
- A chemistry background, with knowledge of the physical and chemical requirements to be considered when developing an API (as salt, cocrystal, solvate, hydrate, etc.) for use in toxicological or clinical studies
- Preferably pharma-industry experience Minimum requirements - PhD in a field relevant to the position or equivalent industry experience
- Fluent oral and written English
- Deep and diverse knowledge in the use of computational solid state modelling software (one or more areas of MM, QM, MD) and simulation methods to characterize, and thus ultimately alter, the physical properties of small organic molecules (preferably active pharmaceutical ingredients)
- Knowledge in the applicability of CCDC CSD Suite, Materials Studio, COSMOtherm, OpenEye, Schrodinger packages desirable; additionally, experience in use of chemical toolkits (such as ChemAxon, OEChem, RDkit) and scientific pipelining tools (such as Pipeline Pilot, Knime)
- Programming experience in scripting languages such as Python; knowledge of UNIX/Linux and high performance computing to perform large calculations
- Experience in crystallography (e.g. crystal structure prediction), crystal engineering, materials science or polymorphism would be advantageous
- Evidence of identifying, developing and applying innovative solutions to scientific and technical problems faced in the life sciences