Heptares is a Drug Discovery Company working on G protein-coupled receptors (GPCRs) involved in CNS and metabolic diseases. Our unique structure-based approach in discovering therapeutic agents for these diseases relies on a proprietary technology to stabilize GPCRs, enabling their purification for structural and biophysical studies.
We are currently seeking an experienced protein biochemist to join our site in Zurich working towards GPCR structure determination to enable drug discovery efforts.
Senior Protein Biochemist - Heptares Zurich
Our preferred candidate will have the following profile:
PhD in biochemistry or related discipline;
Experience in molecular biology;
Experience in membrane protein expression methods in mammalian and insect cells;
Experience in membrane protein purification using AKTA Pure systems;
Experience in preparation of protein for membrane protein crystallization (lipidic cubic phase and vapor diffusion);
Experience in setting up crystallization using automated systems would be an advantage;
Experience in preparing protein and setting up LCP-FRAP of advantage;
Ability to work flexibly within a team whilst being highly self-motivated and work independently;
Analytical thinking and good problem solving skills;
Excellent organizational and time management skills as well as the ability to work to strict deadlines;
Fluency in oral and written English; a knowledge of German is preferred; and,
Relevant lab experience would be preferred.
The successful candidate will be expected to work independently, and the role will include the following responsibilities:
Cloning of plasmid constructs for expression of crystallization constructs;
Expression of GPCRs in insect and mammalian cells;
Characterization of GPCR expression in membrane and in solubilized form;
Construct engineering to optimize GPCRs for crystallization;
Purification of GPCRs and biochemical characterization using a range of analytical techniques such as size exclusion chromatography - develop and optimize processes;
Progression of purified material into crystallization
Careful documentation of experimental work; and,
Work closely with molecular biologists, protein expression scientists, crystallographers and pharmacologists to help advance the project.
This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company.
We offer a competitive salary and benefits package commensurate with qualifications and experience.
Further information can be found on our website (www.heptares.com). Applications should include a covering letter with curriculum vitae including the names and contact details for two referees. Please send your application in pdf format, to firstname.lastname@example.org, quoting reference number 2017_3HZ. The closing date for applications is 15th November 2017.
Heptares Therapeutics Limited
Ms Suzanne Lovell